Here is the intro of Rick's thesis from an eczema sufferer's point of view.... Note numbers in brackets
are Rick's references to other studies (see References). So Rick to speak first......
Skin barrier components have been shown to play a role in the pathogenesis of atopic conditions. When not disrupted, the epidermal structure prevents the exposure of the immune system to known allergens (7) and the loss of moisture retention (9,10,19)
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The opening is interesting as every new GPs, I had seen, asked me if I had asthma or if anyone in the family suffered from the above. Apparently my grand mother used to have "undetermined rashes" and have seen a number of my nephews or relations also suffering from either eczema or some form of dermatitis. Before I go further there is lots of jargon. So thought to collate the terms the GPs have used with me
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Eczema is a generalized inflammation of the dermal barrier (110)
Atopic Dermatitis is a type of eczema and is a chronic inflammatory condition of the skin structure. The result being an inappropriately aggressive reaction by the immune system toward external stimuli or self antigens and a dermatological barrier dysfunction. This is often interchanged with the term "eczema"
Erythematous is the reddening of the skin that occurs with the inflammation......I have noted it doesn't have to be scratched for this to occur.
Xerosis results in dermatitis which appears as erythematous skin with the appearance of dryness. Papular lesions are often present.......This is the starting point and has to be hit on the head with lots of moisturising cream before it becomes worse.
Pruritis is the key symptom of AD (16,44). The pruritis results in what is termed the scratch reflex . The act of scratching causes damage to the epidermis, which results in loss of moisture. The loss of hydration triggers more pruritis, thus perpetuating a cycle of pruritis, scratching, and epidermal damage which results in more pruritis (36, 92).....yes that @#$$^#@! annoying itch that doesn't go away until you've scratched the hell out of it.
Lichenification is a result of longstanding epidermal involvement with repeated scratching. Skin may become disrupted as a function of the general epidermal barrier breakdown. Infectious process can follow this break in the skin resulting in heightened erythema and exudative processes (1).......yeah smelly crusty skin that some of us like to dig and pick when it dries.....
Abstract
The phrase atopic march is applied to the phenomenon of the observed progression of atopic dermatitis (AD) early in life to allergic rhinitis and /or asthma (ref 6,19,115,117) . It has been estimated that 30% of children with AD will develop allergic rhinitis (AR) and a similar number will progress to develop asthma (ref 39,97,117)Skin barrier components have been shown to play a role in the pathogenesis of atopic conditions. When not disrupted, the epidermal structure prevents the exposure of the immune system to known allergens (7) and the loss of moisture retention (9,10,19)
******************************
The opening is interesting as every new GPs, I had seen, asked me if I had asthma or if anyone in the family suffered from the above. Apparently my grand mother used to have "undetermined rashes" and have seen a number of my nephews or relations also suffering from either eczema or some form of dermatitis. Before I go further there is lots of jargon. So thought to collate the terms the GPs have used with me
*******************************
Terms
Eczema is a generalized inflammation of the dermal barrier (110)
Atopic Dermatitis is a type of eczema and is a chronic inflammatory condition of the skin structure. The result being an inappropriately aggressive reaction by the immune system toward external stimuli or self antigens and a dermatological barrier dysfunction. This is often interchanged with the term "eczema"
Erythematous is the reddening of the skin that occurs with the inflammation......I have noted it doesn't have to be scratched for this to occur.
Xerosis results in dermatitis which appears as erythematous skin with the appearance of dryness. Papular lesions are often present.......This is the starting point and has to be hit on the head with lots of moisturising cream before it becomes worse.
Pruritis is the key symptom of AD (16,44). The pruritis results in what is termed the scratch reflex . The act of scratching causes damage to the epidermis, which results in loss of moisture. The loss of hydration triggers more pruritis, thus perpetuating a cycle of pruritis, scratching, and epidermal damage which results in more pruritis (36, 92).....yes that @#$$^#@! annoying itch that doesn't go away until you've scratched the hell out of it.
Lichenification is a result of longstanding epidermal involvement with repeated scratching. Skin may become disrupted as a function of the general epidermal barrier breakdown. Infectious process can follow this break in the skin resulting in heightened erythema and exudative processes (1).......yeah smelly crusty skin that some of us like to dig and pick when it dries.....
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